Spectral affinity in protein networks
نویسندگان
چکیده
منابع مشابه
Protein Identification via Spectral Networks Analysis
Advances in tandem mass-spectrometry (MS/MS) steadily increase the rate of generation of MS/MS spectra. As a result, the existing approaches that compare spectra against databases are already facing a bottleneck, particularly when interpreting spectra of modified peptides. We introduce a new idea that allows one to perform MS/MS database search . . . without ever comparing a spectrum against a ...
متن کاملProtein identification by spectral networks analysis.
While advances in tandem mass spectrometry (MS/MS) steadily increase the rate of generation of MS/MS spectra, standard algorithmic approaches for peptide identification recently seemed to be reaching the limit on the amount of information that could be extracted from MS/MS spectra. However, a closer look reveals that a common limiting procedure is to analyze each spectrum in isolation, even tho...
متن کاملDiffusion Model Based Spectral Clustering for Protein-Protein Interaction Networks
BACKGROUND A goal of systems biology is to analyze large-scale molecular networks including gene expressions and protein-protein interactions, revealing the relationships between network structures and their biological functions. Dividing a protein-protein interaction (PPI) network into naturally grouped parts is an essential way to investigate the relationship between topology of networks and ...
متن کاملAtomic Convolutional Networks for Predicting Protein-Ligand Binding Affinity
Empirical scoring functions based on either molecular force fields or cheminformatics descriptors are widely used, in conjunction with molecular docking, during the early stages of drug discovery to predict potency and binding affinity of a drug-like molecule to a given target. These models require expert-level knowledge of physical chemistry and biology to be encoded as hand-tuned parameters o...
متن کاملRecombinant Production and Affinity Purification of the Mature Form of Staphylolysin (LasA) Protein in E.coli
Background and Aims: Enzybiotics are probably the future line of weapons against drug resistant bacteria. They lyse bacteria with the new mechanisms with few likelihood of generating resistance. LasA, which is secreted from Pseudomonas strains degrades Staphylococcus aureus (S. aureus) cell wall and has the potential to use against drug resistant S. aureus infections. Materials and Metho...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Systems Biology
سال: 2009
ISSN: 1752-0509
DOI: 10.1186/1752-0509-3-112